The Industry Standard, aka thestandard.com, is using Drupal. The Industry Standard features news and analysis that covers emerging technologies and companies, venture funding, acquisitions, site launches, and other developments in the internet space. This system is built as a prediction market, intersected with a reputation-based social network. The site is part of the IDG network, which includes sites like Computerworld, Infoworld, JavaWorld.com, Macworld, PC World, and more.
Like most big Drupal sites, they use CCK, Views, memcache, and a master-slave database configuration. Two noteworthy items are the fact that they use Apache Solr for search, and Mollom as their spam deterrent.